Hi Jonathan,
our configuration is like
<VirtualHost *:80>
ServerName servername.mendix.nl
DocumentRoot /srv/mxinstances/servername/web/
ProxyPass /xas http://[::1]:8100/xas retry=0
ProxyPassReverse /xas http://[::1]:8100/xas
Proxypass /file http://[::1]:8100/file retry=0
Proxypassreverse /file http://[::1]:8100/file
</VirtualHost>
So beside using other ports and the file servlet, there seem to be no real difference. Furthermore this is about the bare HTTP protocol, so intuitively i would say that there is nothing wrong with the configuration (especially since firefox works) but that the problem lies elsewhere.
Are you using custom widgets? Did you try browse to the server using a different machine? Did you empty the cache in IE a few times? (especially when another mendix product was running on the same URL before).