And is this deployed locally? If so, what does your environment look like in terms of server and database?
Update 1
Next questions:
Check out this technet article and see if anything makes sense there. Also take a look at this page.
I think that it has to do with the setting: ConnectionPoolingMaxActive which is now set to 100 and the ConnectionPoolingMaxWait setting. Will set the ConnectionPoolingMaxActive to 150 and monitor this.