AWS rdsbroker failed with SQLState 08001

We’re having an issue with our App, it’s unresponsive and the live log is showing: Opening JDBC connection to Some( failed with SQLState: 08001 Error code: 0 Message: Connection attempt timed out., giving up...(4/4) No changes have been made to cause this error, a publish of the app (to give it  a kick) has no impact Any ideas? Support is not on their best form helping with this, so asking the wider community.
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