Does more Database Connection trigger the Database Freeable Memory alerts ?

We get Database Freeable Memory alerts almost every day during office hours. And observed that during the time application has occupied all the database connections ( 50 ) Even though the number of concurrent users is not more than 20-30, alerts get triggered. Surprisingly during weekends or out of office hours we are not getting any database freeable memory alerts  I have also tracked the running now but have not found a thread.   What will be the reason for this?      
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