If you're doing an exact match check in a microflow you can trim the time-specific information from the datetime by using the trimToDays or trimToDaysUTC functions. If you trim both parts of your check to days, you can check for an exact match.
If you're working with retrieves from database, and your dateTimes aren't trimmed before saving, you could opt to retrieve with a range where your datetime is bigger or equal to value A and smaller than value B. Where A is the start of that day, and B is the start of the following day.
Be sure to check your datetime comparisons for localisation and utc though. Otherwise you'll be retrieving the wrong dates.
You can find more information here https://docs.mendix.com/refguide/trim-to-date