It looks like all the changes are in the Advanced Excel module. There were quite some deprecations between Mendix 10.18.0 and 10.21.1, so it's quite possible that the module doesn't support the newer Mendix version yet. I'd contact the creator and ask.
But I am getting changes from different modules also, not only that advanced Excel, all changes are Java changes.
I was also trying to update all the third-party modules to the latest version after that also, the same issue I am facing while running the application.
When I am double-clicking on any Java changes, it is showing the same as below for all.