Page Layout concern

Hi , I am facing an issue of layout set up of pages. The page designed on one desktop size is different when opened in different screen size (both on 100% resolution), like page designed on big screen monitor looks different when it looked in laptop or small screen desktop. (The graphs look overlapped or text font size get varied,etc) Please let me  know what’s the criteria for page setup & how to do it efficiently so that I can develop apps with better UI. Regards, Kirti 
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